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Thermo Fisher

LTQ Orbitrap XL Mass

The Thermo Fisher LTQ Orbitrap XL Mass Spectrometer is a hybrid FT mass spectrometer. The Thermo Fisher LTQ Orbitrap XL Mass Spectrometer combines a linear ion trap and an Orbitrap mass analyzer. The Thermo Fisher LTQ Orbitrap XL Mass Spectrometer has a maximum resolution of 100,000.[1][2]

LTQ Orbitrap XL Mass — Inventory photo
Fig. 01LTQ Orbitrap XL MassInventory photo[2]

Vacuum

Two Mechanical Pumps[2]

Optics

100,000[2]

What it is

The LTQ Orbitrap XL Mass Spectrometer is a hybrid ion trap-Orbitrap mass spectrometer.[4][1]

The LTQ Orbitrap XL combines a linear ion trap with an Orbitrap mass analyzer.[3][1]

The LTQ Orbitrap XL is used for liquid chromatography mass spectrometry workflows and related mass spectrometric analysis.[4][3]

How it works

A hybrid ion trap-Orbitrap mass spectrometer generates ions in an atmospheric-pressure ion source, collects them in the linear ion trap, and transfers them to the Orbitrap analyzer for detection.[1]

The LTQ Orbitrap XL uses a C-trap to store and collisionally cool ions before injection into the Orbitrap mass analyzer.[1][3]

The LTQ Orbitrap XL detects image current from ion packets in the Orbitrap and converts the signal by fast Fourier transformation into a mass spectrum.[1]

The LTQ Orbitrap XL supports collision-induced dissociation in the ion trap and higher-energy collisional dissociation in the HCD collision cell.[1][3]

Where it fits in the process flow

General reference — not yet source-verified

The LTQ Orbitrap XL sits in the analytical mass spectrometry stage of a workflow after sample introduction and ion generation.

The LTQ Orbitrap XL is used for tandem mass spectrometry measurements on complex mixtures, where it can support identification, structural analysis, and quantitation.

Applications

The LTQ Orbitrap XL is used in proteomics for protein identification, peptide sequencing, and biomarker-related analysis.[1]

The LTQ Orbitrap XL is used in metabolite profiling and metabolomics studies.[1]

What do the numbers mean?

Power & electrical2

Powervar 2000 GPI - Voltage Line Conditioner[2]
Accurate?
Power requirements
230 Vac ±10% 3 phase, 16 Amps, 50/60 Hz, with earth ground for the instrument[1]
Accurate?

Vacuum & pumping1

Two Mechanical Pumps[2]
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Gas & chemistry1

Gas supply
One high purity (99.5% pure, flow rate 15 L/min) nitrogen gas supply for the API source; one ultra-high-purity helium gas supply (99.998%) with less than 1 ppm each of water, oxygen, and total hydrocarbons for the linear ion trap[1]
Accurate?

Optics & imaging4

Max Resolution
100,000[2]
Accurate?
Maximum resolution
100,000[2]
Accurate?
Resolution (apodized)
60,000 (FWHM) at m/z 400 with a scan repetition rate of 1 second[3]
Accurate?
Minimum resolution
7,500 at m/z 400[3]
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Performance1

Mass accuracy
<3 ppm RMS for 2 h period with external calibration using defined conditions; <2 ppm RMS with internal calibration[3]
Accurate?

Dimensions & facilities2

Mass spectrometer dimensions
141.4 × 87 × 146.3 cm (H × W × D)[1]
Accurate?
Mass spectrometer weight
~600 kg[1]
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Configuration & options9

IonMax ESI Source[2]
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Chiller[2]
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Model
LTQ Orbitrap XL[2]
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Make
Thermo Scientific[2]
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Ion source
IonMax ESI Source[2]
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Mass range
m/z 50–2000; m/z 200–4000[3]
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Dynamic range
>10000 between mass spectra; >4000 between highest and lowest detectable mass in one spectrum[3]
Accurate?
Collision cell
HCD collision cell[3]
Accurate?
Recirculating chiller
Thermo Scientific ThermoFlex 900[3]
Accurate?
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What does it need to run?

Site utility requirements, footprint, and infrastructure needed to install and operate this tool. Sourced from public records.

  • ConfigurationTwo Mechanical Pumps[2]
  • ConfigurationPowervar 2000 GPI - Voltage Line Conditioner[2]
  • Power requirements230 Vac ±10% 3 phase, 16 Amps, 50/60 Hz, with earth ground for the instrument[1]
  • Gas supplyOne high purity (99.5% pure, flow rate 15 L/min) nitrogen gas supply for the API source; one ultra-high-purity helium gas supply (99.998%) with less than 1 ppm each of water, oxygen, and total hydrocarbons for the linear ion trap[1]

Where are the manuals?

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Not publicly documented

Field notes

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Not publicly documented

The following facts about the LTQ Orbitrap XL Mass are absent from this record as of this revision. First-hand knowledge or a citation closes a gap; every submission is reviewed before publication.

  • No publicly documented production dates or lifecycle milestones (introduction, end of production, EOL) for the LTQ Orbitrap XL Mass are on record.

    Answerable by: OEM historical records or a trade-press announcement

  • No publicly documented variants, configuration options, or revision breakpoints of the LTQ Orbitrap XL Mass are on record.

    Answerable by: an OEM product catalog or an engineer who ordered or specified the tool

  • The control-system platform and OS era of the LTQ Orbitrap XL Mass are not on record.

    Answerable by: an engineer who operated it or OEM installation records

  • No publicly documented failure modes or field errata for the LTQ Orbitrap XL Mass are on record.

    Answerable by: a field service engineer, process engineer, or maintenance technician

  • The process node or technology generation of the LTQ Orbitrap XL Mass is not on record.

    Answerable by: an OEM datasheet or a fab qualification report

No research found yet — worked with this tool? Share what you know.

Sources & citations

Sources (4)Every fact above is drawn from these public sources
  1. [1]documents.thermofisher.com — documents.thermofisher.comdocuments.thermofisher.com
  2. [2]Inventory photo
  3. [3]docs.thermofisher.com — docs.thermofisher.comdocs.thermofisher.com
  4. [4]LTQ Orbitrap XL Hybrid Ion Trap-Orbitrap Mass Spectrometer Support | Thermo Fisher Scientific - US — thermofisher.comthermofisher.com
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Last updated Oct 11, 2026.

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